Irregular RPE Baseline Elevation Linked to Higher Neovascular Risk in Pachychoroid Eyes

A recent multicenter cohort study published in JAMA Ophthalmology indicates that eyes with a pachychoroid subtype generally remain stable over a two-year period. However, neovascularization, a rare occurrence, was exclusively observed in eyes that presented with shallow, irregular retinal pigment epithelium (RPE) elevation at baseline. This finding highlights the importance of this imaging feature as a potential biomarker for risk stratification in pachychoroid eyes.