Higher p-tau217 Levels and APOE-ε4 Genotype Linked to Increased Cognitive Impairment Risk

A pooled analysis published in The Lancet Neurology indicates that elevated plasma phosphorylated tau 217 (p-tau217) levels are associated with a greater risk of cognitive impairment, particularly in adults carrying the apolipoprotein E ε4 (APOE-ε4) allele. The findings suggest that APOE genotype can provide additional prognostic information, potentially improving risk stratification for cognitive decline.