NOHARM Trial Demonstrates Reduced Postoperative Opioid Exposure with Nondrug Pain Management

A new study, the NOHARM trial, published in JAMA Network Open, found that a strategy promoting nondrug pain management after surgery significantly reduced patients' exposure to opioids without worsening pain interference, physical function, or other patient-reported outcomes. This research, led by a team from Mayo Clinic, involved a cluster randomized trial across six high-volume surgical centers and supports the integration of nondrug approaches into postoperative pain management to mitigate risks associated with prolonged opioid use.