Global Experts Issue New Guidance for CAR T-Cell Therapy in Severe Autoimmune Diseases

International experts have released updated best-practice recommendations for the use of CAR T-cell therapy in severe autoimmune diseases, reflecting a surge in clinical experience since the initial guidance in 2024. The new framework, published in The Lancet Rheumatology, provides comprehensive guidance on patient selection, diagnostic assessment, treatment planning, clinical management, follow-up, and immune monitoring across various indications including rheumatological, neurological, haematological, and paediatric conditions.