Global Experts Issue Updated Guidance for CAR T-Cell Therapy in Severe Autoimmune Diseases

An international panel of specialists has published a comprehensive update to the guidelines for using chimeric antigen receptor (CAR) T-cell therapy in severe autoimmune diseases, appearing in The Lancet Rheumatology. These 2026 recommendations reflect a significant increase in clinical experience and aim to establish scientific discipline for this powerful immunotherapy, ensuring patient safety as its application expands from oncology to rheumatology.