Research Suggests Ketamine-Buprenorphine Combination May Extend Anti-Suicidal Effects

A recent randomized controlled trial suggests that adjunctive low-dose buprenorphine following a single ketamine infusion may prolong reductions in suicidal ideation for up to one month. These preliminary findings, published online today, offer a potential pharmacologic bridge for patients in suicidal crisis while they engage with ongoing psychiatric care, though further replication in larger studies is needed before routine clinical practice.