Extraoral and Intraoral Light Therapy Show Comparable Efficacy in Preventing Oral Mucositis in Pediatric Cancer Patients

A single-blind randomized controlled trial found that extraoral red-light photobiomodulation is a credible alternative to intraoral treatment for preventing oral mucositis in children receiving high-dose methotrexate for cancer. The study, published in Supportive Care in Cancer, suggests the need for multicenter trials to confirm findings and optimize pediatric protocols.