PROSpect Trial Finds No Benefit for Prone Positioning or High-Frequency Ventilation in Pediatric ARDS

The PROSpect trial, published in The Lancet, concluded that routine use of prone positioning or high-frequency oscillatory ventilation (HFOV) did not improve ventilator-free days in children with moderate-to-severe pediatric acute respiratory distress syndrome (PARDS). These negative findings challenge existing "standard of care" practices, suggesting that the evidence for these interventions was not robust.