Study: Prone Positioning and HFOV Ineffective for Pediatric ARDS

A large international trial, PROSpect, published in The Lancet, found no evidence that routine prone positioning or high-frequency oscillatory ventilation (HFOV) improve ventilator-free days in early, moderate-to-severe pediatric acute respiratory distress syndrome (PARDS). The study was halted early due to futility and slow enrollment. This suggests these strategies are not recommended as first-line treatments for this patient population, potentially influencing clinical guidelines.