PROSpect Trial Concludes Prone Positioning and High-Frequency Oscillatory Ventilation Ineffective for Pediatric ARDS

The PROSpect trial, published in The Lancet, has found that routine use of prone positioning and high-frequency oscillatory ventilation (HFOV) does not improve ventilator-free days in children with early, moderate-to-severe pediatric acute respiratory distress syndrome (PARDS). This significant finding challenges long-standing practices in pediatric intensive care units worldwide, where these interventions were often used without definitive randomized evidence.