CT-Guided PCI Non-Inferior to IVUS for Coronary Intervention Outcomes, P4 Trial Shows

New landmark randomized clinical data from the 1,105-patient P4 trial, simultaneously published in the New England Journal of Medicine (NEJM) and presented at Transcatheter Cardiovascular Therapeutics (TCT) 2026, demonstrates that CT-guided percutaneous coronary intervention (PCI) planning is non-inferior to gold-standard intravascular ultrasound (IVUS) for one-year clinical outcomes. This approach also significantly improved procedural efficiency, leading to faster procedure times and lower contrast volume.