New Study Identifies Antidepressants Most Effective for Long-Term Depression Treatment

A significant comparative study published in *The Lancet Psychiatry* has identified escitalopram, agomelatine, and duloxetine as the most effective antidepressants for not only alleviating depression symptoms in the short term but also sustaining these benefits over the longer term. This large-scale research, which analyzed data from 115 randomized clinical trials involving over 30,000 participants, is the first to compare various antidepressants for both short- and long-term efficacy. The findings are expected to inform the initial choice of antidepressants, particularly considering their potential for prolonged use.