CDC Investigators Recommend Tailored Treatment for Enteric Fever Due to Rising Drug Resistance

CDC investigators advise that enteric fever (typhoid or paratyphoid fever) infections in travelers returning to the U.S. are increasingly resistant to ciprofloxacin, and some cases also show resistance to 'first-choice' antimicrobials like ceftriaxone. They recommend that treatment be guided by susceptibility testing whenever possible, especially for travelers returning from high-risk destinations such as the Indian subcontinent.