3D Genome Mapping in Rare Immune Cells Uncovers New Crohn's Disease Genes

A new study co-led by Prof. Valeriya Malysheva at the VIB-UAntwerp Center for Molecular Neurology, published in Nature Genetics, reveals how the three-dimensional organization of DNA in rare immune cells contributes to the genetic risk of Crohn's disease and other autoimmune conditions. This research moves beyond a linear view of the genome, focusing on how DNA folding brings distant regulatory regions into contact with the genes they control.