Method Discovered to Reactivate Gene Linked to Friedreich's Ataxia

Researchers at St. Jude Children's Research Hospital have identified a method to reactivate the frataxin gene, which is silenced in Friedreich's ataxia. Published in Nature Cell Biology, the study reveals a synthetic gene regulator can activate the gene by navigating tightly packaged DNA, challenging prior assumptions about histone modifications. This discovery offers potential new therapeutic avenues for the neurodegenerative condition.