mRNA Immunotherapy Developed by UMass Chan Scientists Eliminates Pancreatic Tumors in Mice

Scientists at UMass Chan Medical School have developed an mRNA immunotherapy cocktail that successfully eliminated pancreatic tumors in approximately 50% of treated mice, with the mice remaining disease-free for a year after treatment cessation. Published in Nature Communications, this strategy combines immune cytokine and tumor-associated antigen mRNAs and shows potential as a modular platform for treating other immune-resistant cancers.