p53 Loss Promotes Cancer Cell Growth by Altering Wnt Signaling Pathway

A Mount Sinai study published in *Science* reveals how the loss of tumor suppressor protein p53, often mutated in cancers, enables mutant cells to expand through normal tissue. Researchers found that p53 loss reorganizes the Wnt signaling pathway into a radial gradient, which is crucial for efficient mutant clone expansion. This discovery provides a novel mechanism for understanding cancer progression.