New Framework Explains Rarity of Genetic Interactions in Genome-Wide Analyses

A new framework published by Oxford Academic aims to reconcile the theoretical prevalence of genetic interactions, or epistasis, with their infrequent detection in genome-wide analyses. The study suggests current methods, which often focus on pairwise interactions, may underestimate epistasis. This work could lead to improved approaches for identifying epistatic redundancy in genetic studies and evolving populations, enhancing understanding of complex genetic traits.