MIT Researchers Develop mRNA-Delivering Nanoparticles to Generate CAR NK Cells In Vivo for Cancer and Autoimmunity

Researchers at MIT have engineered lipid nanoparticles that can deliver messenger RNA (mRNA) directly to natural killer (NK) cells within the body, leading to the in vivo generation of functional chimeric antigen receptor (CAR) NK cells. This innovative approach has demonstrated effectiveness in eliminating tumors in mouse models of cancer and reducing liver damage in models of autoimmune hepatitis, offering a potential new avenue for CAR-based immunotherapy.