Hidden Tumor Antigens Identified, Potentially Expanding Colorectal Cancer Immunotherapy

A new study published in *Molecular & Cellular Proteomics* challenges previous assumptions about immunotherapy for colorectal cancer. Researchers found that treatment-resistant microsatellite-stable (MSS) colorectal tumors, which typically respond poorly to immunotherapy, harbor tumor antigens capable of triggering immune recognition. This discovery could lead to new strategies for expanding effective immunotherapy to a broader range of colorectal cancer patients.