New Gold-Coated Fiber-Optic Biosensor Developed for Label-Free Detection of Cancer Cells

A gold-coated, polydimethylsiloxane (PDMS)-based extrinsic semi-distributed interferometric (SDI) optical fiber biosensor, functionalized with anti-CD44 antibodies, has been developed for the label-free and selective detection of CD44-expressing HCC1806 breast cancer cells. This new biosensor exhibited a concentration-dependent response with a low limit of detection, offering a promising groundwork for tumor-cell diagnostics.