New Study Identifies Vulnerability in Liver Cancer Cells, Paving Way for Potential New Therapies

A study led by the Vall d'Hebron Institute of Oncology (VHIO), published in PNAS, has identified a critical vulnerability in liver cancer cells. The research shows that simultaneous inactivation of two proteins, CDK16 and CDK18, which regulate nuclear transport and DNA repair, leads to persistent DNA damage and tumor cell death. This discovery opens new avenues for developing targeted therapies.