Human-Specific TAF8 Isoform Diversifies TFIID General Transcription Factor Composition

An accepted manuscript published in Genetics identifies a human-specific TAF8 isoform that diversifies the composition of the TFIID general transcription factor. This finding suggests that alternative transcript isoforms can generate new protein interactions and molecular complexity in essential cellular machineries, with potential implications for TAF-related developmental disorders. This work is an accepted manuscript and is therefore preliminary, awaiting final copyediting and typesetting.